Naproxen

Category: pharmacological

Aliases: Aleve, Naprosyn

Pharmacological Mechanism

Reversible non-selective COX inhibitor. Favorable long t½ (~15 h) → twice-daily dosing. CV safety profile reportedly better than other NSAIDs in meta-analyses (PRECISION trial).

Half-Life (t½)

PO: 15h

Dosing Guidelines

• PO: Typical 313mg (Range: 220 - 500 mg)

Target Organ Systems

• musculoskeletal
• cardiovascular

Interactions

• Warfarin