Naltrexone

Category: pharmacological

Aliases: Vivitrol, ReVia

Pharmacological Mechanism

Pure µ-opioid receptor antagonist — competitive blockade with no agonist activity. Approved for alcohol use disorder + opioid use disorder relapse prevention. Hepatotoxicity warning at high doses (>300 mg/d). LDN at 1–4.5 mg used off-label for autoimmune / fibromyalgia.

Half-Life (t½)

PO: 4h, IM: 4h

Dosing Guidelines

• PO: Typical 50 mg (Range: 25–100 mg)

Target Organ Systems

• nervous
• digestive
• musculoskeletal
• immune-hematologic

Pathways It Modulates

• Opioid receptor signaling (inhibitor) — μ-opioid (competitive antagonist) + κ

Chemical Identifiers

• PubChem CID: 5360515
• Formula: C20H23NO4
• Molecular weight: 341.4 g/mol
• InChIKey: DQCKKXVULJGBQN-XFWGSAIBSA-N
• SMILES: C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O

References

• PMID 6114837