Naltrexone

Category: pharmacological

Aliases: Vivitrol, ReVia

Pharmacological Mechanism

Pure µ-opioid receptor antagonist — competitive blockade with no agonist activity. Approved for alcohol use disorder + opioid use disorder relapse prevention. Hepatotoxicity warning at high doses (>300 mg/d). LDN at 1–4.5 mg used off-label for autoimmune / fibromyalgia.

Half-Life (t½)

PO: 4h, IM: 4h

Dosing Guidelines

• PO: Typical 50mg (Range: 25 - 100 mg)

Target Organ Systems

• nervous
• digestive
• musculoskeletal
• immune-hematologic