Category: pharmacological
Aliases: Corgard
Long-acting non-selective β-adrenergic blocker. Renally cleared (no CYP), preferred in liver disease. Used for hypertension, angina, esophageal varices prophylaxis. Once-daily dosing. PK (Corgard label + Kalsoom 2022 systematic review PMID:35243668): F ~30–35% (poor oral absorption — hydrophilic β-blocker), apparent Vd ~1.9 L/kg (~135 L), t½ 17–23 h (allowing once-daily dosing), Tmax 3–4 h. ~75% renally excreted unchanged — accumulates in renal impairment. Steady state by day 3. Binds primarily to α₁-acid glycoprotein, free fraction ~0.7.
PO: 9.1h