Category: amino-acid
Aliases: NACA, AD4, NAC amide
The carboxylate of NAC is replaced with an amide — neutralises the molecule's negative charge, producing a lipophilic thiol that crosses membranes (including the blood-brain barrier) 4–5× more efficiently than NAC. In vivo it is hydrolysed by amidases to NAC and thence to cysteine, feeding glutathione synthesis. Also acts directly as a free-thiol antioxidant and Cu²⁺ chelator in the CNS. Investigated for CNS oxidative-stress indications (traumatic brain injury, retinal degeneration, Parkinson's models) and for GSH-depleted states where NAC penetration is limiting. Murine PK (He 2020): IV Cmax ~250 µg/mL, t½ ~1 h; oral F ~10%.