Molnupiravir

Category: pharmacological

Aliases: Lagevrio

Pharmacological Mechanism

Ribonucleoside prodrug — phosphorylated to a pseudo-cytidine analog incorporated by SARS-CoV-2 RNA polymerase, inducing lethal mutagenesis (error catastrophe). Less efficacious than Paxlovid; used when Paxlovid is contraindicated or inaccessible.

Half-Life (t½)

PO: 3h

Dosing Guidelines

• PO: Typical 800mg (Range: 800 - 800 mg)

Target Organ Systems

• immune-hematologic