Menaquinone-7 (MK-7)

Category: vitamin

Aliases: Vitamin K2 MK-7, Natto-derived K2

Pharmacological Mechanism

Long 7-isoprenoid side chain → much longer plasma t½ (~68 h) than MK-4 (~1 h). Same Gla-protein carboxylation as MK-4 but steadier exposure with once-daily dosing. Produced by gut bacteria and by Bacillus subtilis natto fermentation.

Half-Life (t½)

PO: 68h

Dosing Guidelines

• PO: Typical 133mcg (Range: 100 - 200 mcg)

Target Organ Systems

• cardiovascular
• musculoskeletal

Interactions

• Vitamin D3
• Warfarin
• MK-4