Mirabegron

Category: pharmacological

Aliases: Myrbetriq

Pharmacological Mechanism

β3-adrenergic agonist — relaxes detrusor smooth muscle without anticholinergic side-effect burden. Preferred over oxybutynin / tolterodine in elderly. CYP2D6 inhibitor — caution with metoprolol, antidepressants. Modest BP elevation.

Half-Life (t½)

PO: 50h

Dosing Guidelines

• PO: Typical 50 mg (Range: 25–50 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Bladder detrusor pharmacology (activator) — β3-adrenergic (detrusor)
• Brown adipose thermogenesis (activator) — β3-AR (FDA-approved for OAB; off-label BAT activation trials)
• Muscarinic ACh receptor subtypes (activator) — β3-AR (alternative to mAChR for overactive bladder)

Chemical Identifiers

• PubChem CID: 9865528
• Formula: C21H24N4O2S
• Molecular weight: 396.51 g/mol
• InChIKey: PBAPPPCECJKMCM-IBGZPJMESA-N
• SMILES: C1=CC=C(C=C1)[C@H](CNCCC2=CC=C(C=C2)NC(=O)CC3=CSC(=N3)N)O

References

• PMID 25791612