Mifepristone

Category: hormone

Aliases: RU-486, Korlym

Pharmacological Mechanism

Progesterone receptor antagonist + glucocorticoid receptor antagonist. Combined with misoprostol for medical abortion (≤10 weeks). Korlym formulation for hyperglycemia in Cushing syndrome leverages the GR antagonism.

Half-Life (t½)

PO: 18h

Dosing Guidelines

• PO: Typical 200mg (Range: 200 - 600 mg)

Target Organ Systems

• endocrine