Miconazole

Category: topical

Aliases: Monistat

Pharmacological Mechanism

Imidazole antifungal — fungal CYP51 inhibitor. OTC topical + intravaginal for cutaneous + vulvovaginal candidiasis. Oral gel formulation (for thrush) carries CYP3A4 inhibition concerns from systemic absorption — interaction with warfarin + statins.

Half-Life (t½)

TD: 24h

Dosing Guidelines

• TD: Typical 100mg (Range: 20 - 200 mg)

Target Organ Systems

• cardiovascular
• digestive
• integumentary
• immune-hematologic