Miconazole

Category: topical

Aliases: Monistat

Pharmacological Mechanism

Imidazole antifungal — fungal CYP51 inhibitor. OTC topical + intravaginal for cutaneous + vulvovaginal candidiasis. Oral gel formulation (for thrush) carries CYP3A4 inhibition concerns from systemic absorption — interaction with warfarin + statins.

Half-Life (t½)

TD: 24h

Dosing Guidelines

• TD: Typical 100 mg (Range: 20–200 mg)

Target Organ Systems

• cardiovascular
• digestive
• integumentary
• immune-hematologic

Pathways It Modulates

• Fungal ergosterol biosynthesis (inhibitor) — fungal CYP51

Chemical Identifiers

• PubChem CID: 4189
• Formula: C18H14Cl4N2O
• Molecular weight: 416.13 g/mol
• InChIKey: BYBLEWFAAKGYCD-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl