Mexiletine

Category: pharmacological

Aliases: Mexitil

Pharmacological Mechanism

Class IB antiarrhythmic — voltage-gated Na+ channel blocker preferentially binding the inactivated state. Used for ventricular arrhythmias + neuropathic pain (off-label) + myotonic syndromes. CYP2D6 substrate.

Half-Life (t½)

PO: 17h

Dosing Guidelines

• PO: Typical 200 mg (Range: 150–300 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Cardiac action potential (inhibitor) — Na+ channel (class IB)

Chemical Identifiers

• PubChem CID: 4178
• Formula: C11H17NO
• Molecular weight: 179.26 g/mol
• InChIKey: VLPIATFUUWWMKC-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)OCC(C)N

References

• PMID 6662176