Metolazone

Category: pharmacological

Aliases: Zaroxolyn

Pharmacological Mechanism

Thiazide-like diuretic — same NCC blockade as HCTZ but works synergistically with loop diuretics in diuretic-resistant heart failure. Powerful natriuresis when sequentially blocking distal tubule downstream of loop-treated proximal segments.

Half-Life (t½)

PO: 14h

Dosing Guidelines

Target Organ Systems