Metoclopramide

Category: pharmacological

Aliases: Reglan

Pharmacological Mechanism

Dopamine D2 antagonist (CTZ + GI tract) + 5-HT4 agonist + 5-HT3 antagonist. Antiemetic + prokinetic for diabetic gastroparesis. EPS + tardive dyskinesia risk → black-box warning at chronic use > 12 weeks.

Half-Life (t½)

PO: 5.2h, IV: 5.2h

Dosing Guidelines

• PO: Typical 10mg (Range: 5 - 15 mg)

Target Organ Systems

• nervous
• digestive