Metoclopramide

Category: pharmacological

Aliases: Reglan

Pharmacological Mechanism

Dopamine D2 antagonist (CTZ + GI tract) + 5-HT4 agonist + 5-HT3 antagonist. Antiemetic + prokinetic for diabetic gastroparesis. EPS + tardive dyskinesia risk → black-box warning at chronic use > 12 weeks.

Half-Life (t½)

PO: 5.2h, IV: 5.2h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–15 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Dopamine receptor signaling (inhibitor) — D2 (area postrema + GI)

Chemical Identifiers

• PubChem CID: 4168
• Formula: C14H22ClN3O2
• Molecular weight: 299.8 g/mol
• InChIKey: TTWJBBZEZQICBI-UHFFFAOYSA-N
• SMILES: CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl

References

• PMID 12593651
• PMID 11489465