Methylene Blue

Category: pharmacological

Aliases: Methylthioninium chloride

Pharmacological Mechanism

Phenothiazine dye — at low doses (0.5–4 mg/kg) acts as a mitochondrial alternate electron carrier (cytochrome c shunt) + MAO-A inhibitor. Used clinically for methemoglobinemia + ifosfamide encephalopathy. Biohacker interest in low-dose for cognition + mitochondrial support; serotonin syndrome risk with SSRIs at higher doses.

Half-Life (t½)

PO: 5.25h, IV: 5.25h

Dosing Guidelines

Target Organ Systems