Methyldopa

Category: pharmacological

Aliases: Aldomet

Pharmacological Mechanism

Centrally-acting α2-adrenergic agonist (active metabolite α-methylnorepinephrine) — reduces sympathetic outflow. Preferred antihypertensive in pregnancy with the longest safety record. Hemolytic anemia + hepatotoxicity at chronic use.

Half-Life (t½)

PO: 2h, IV: 2h

Dosing Guidelines

Target Organ Systems