Mesalamine

Category: pharmacological

Aliases: 5-ASA, 5-aminosalicylic acid, Mesalazine

Pharmacological Mechanism

Active anti-inflammatory metabolite of sulfasalazine — local action in colon mucosa via COX/LOX inhibition + scavenging of reactive oxygen species. First-line for mild-to-moderate ulcerative colitis; pH- and time-controlled formulations target distal ileum/colon.

Half-Life (t½)

PO: 1.4h

Dosing Guidelines

• PO: Typical 2400mg (Range: 800 - 4800 mg)

Target Organ Systems

• digestive
• immune-hematologic