Mesalamine

Category: pharmacological

Aliases: 5-ASA, 5-aminosalicylic acid, Mesalazine

Pharmacological Mechanism

Active anti-inflammatory metabolite of sulfasalazine — local action in colon mucosa via COX/LOX inhibition + scavenging of reactive oxygen species. First-line for mild-to-moderate ulcerative colitis; pH- and time-controlled formulations target distal ileum/colon.

Half-Life (t½)

PO: 1.4h

Dosing Guidelines

• PO: Typical 2400 mg (Range: 800–4800 mg)

Target Organ Systems

• digestive
• immune-hematologic

Pathways It Modulates

• IBD mucosal immunomodulation (inhibitor) — 5-aminosalicylic acid (PPAR-γ + COX + NF-κB locally)

Chemical Identifiers

• PubChem CID: 4075
• Formula: C7H7NO3
• Molecular weight: 153.14 g/mol
• InChIKey: KBOPZPXVLCULAV-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1N)C(=O)O)O

References

• PMID 8141827