Meropenem

Category: pharmacological

Aliases: Merrem

Pharmacological Mechanism

Carbapenem β-lactam — very broad spectrum (gram-positive, gram-negative including Pseudomonas + ESBL producers, anaerobes). Reserved for severe infections + ESBL-producing organisms. Lower seizure risk than imipenem.

Half-Life (t½)

IV: 1h

Dosing Guidelines

• IV: Typical 1000 mg (Range: 500–2000 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP (carbapenem)

Chemical Identifiers

• PubChem CID: 441130
• Formula: C17H25N3O5S
• Molecular weight: 437.52 g/mol
• InChIKey: DMJNNHOOLUXYBV-PQTSNVLCSA-N
• SMILES: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O

References

• PMID 2055812