Menthol

Category: terpenoid

Aliases: (-)-menthol

Pharmacological Mechanism

Cyclic monoterpene from Mentha species. Activates TRPM8 cold-receptor channels → cooling sensation; also weak Ca²⁺-channel modulation. Topical analgesic, decongestant, GI antispasmodic.

Half-Life (t½)

PO: 1.5h

Dosing Guidelines

• PO: Typical 180mg (Range: 90 - 270 mg)

Target Organ Systems

• nervous