Medroxyprogesterone

Category: hormone

Aliases: Provera, Depo-Provera, MPA, medroxyprogesterone acetate

Pharmacological Mechanism

Synthetic progestin (17α-hydroxyprogesterone derivative). Agonizes the progesterone receptor; suppresses pituitary LH/FSH to inhibit ovulation, thickens cervical mucus, transforms endometrium. Oral (HRT/amenorrhea/oncology) + IM depot (q3-month contraception).

Half-Life (t½)

PO: 50h, IM: 50h

Dosing Guidelines

• PO: Typical 5 mg (Range: 2.5–10 mg)
• IM: Typical 150 mg (Range: 150–150 mg)

Target Organ Systems

• endocrine
• reproductive

Chemical Identifiers

• PubChem CID: 10631
• Formula: C22H32O3
• Molecular weight: 386.52 g/mol
• InChIKey: FRQMUZJSZHZSGN-HBNHAYAOSA-N
• SMILES: C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)O)C)[C@@]4(C1=CC(=O)CC4)C

References

• PMID 2943134
• PMID 1388093
• PMID 2971841