Meclizine

Category: pharmacological

Aliases: Antivert, Bonine

Pharmacological Mechanism

First-generation H1 antagonist + mild anticholinergic — selectively reduces vestibular nausea / motion sickness. OTC for motion sickness; off-label for vertigo + Meniere disease.

Half-Life (t½)

PO: 7.4h

Dosing Guidelines

• PO: Typical 25mg (Range: 12.5 - 100 mg)

Target Organ Systems

• nervous