Meclizine

Category: pharmacological

Aliases: Antivert, Bonine

Pharmacological Mechanism

First-generation H1 antagonist + mild anticholinergic — selectively reduces vestibular nausea / motion sickness. OTC for motion sickness; off-label for vertigo + Meniere disease.

Half-Life (t½)

PO: 7.4h

Dosing Guidelines

• PO: Typical 25 mg (Range: 12.5–100 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Histamine receptor pharmacology (inhibitor) — H1 + muscarinic

Chemical Identifiers

• PubChem CID: 4034
• Formula: C25H27ClN2
• Molecular weight: 391.94 g/mol
• InChIKey: OCJYIGYOJCODJL-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl

References

• PMID 37428729