Matrixyl

Category: peptide

Aliases: Palmitoyl Pentapeptide-4, Pal-KTTKS

Pharmacological Mechanism

Lipid-conjugated KTTKS pentapeptide — mimics the procollagen-I C-terminal cleavage fragment; signals dermal fibroblasts to upregulate collagen + fibronectin synthesis. Topical anti-aging actives at 2–10 mg/g formulations.

Half-Life (t½)

TD: 6h

Dosing Guidelines

• TD: Typical 2 mg (Range: 0.5–5 mg)

Target Organ Systems

• integumentary

Pathways It Modulates

• Antimicrobial + cosmetic peptides (activator) — fibroblast collagen synthesis

Chemical Identifiers

• PubChem CID: 9897237
• Formula: C39H75N7O10
• Molecular weight: 802.05 g/mol
• InChIKey: WSGCRSMLXFHGRM-DEVHWETNSA-N
• SMILES: CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O