Lorazepam

Category: pharmacological

Aliases: Ativan

Pharmacological Mechanism

Benzodiazepine with direct glucuronidation (no CYP metabolism, no active metabolites) — preferred in hepatic impairment + elderly. First-line for status epilepticus (faster CNS onset than diazepam and no long-acting metabolites).

Half-Life (t½)

PO: 14h, IV: 14h, SL: 14h

Dosing Guidelines

• PO: Typical 1mg (Range: 0.5 - 2 mg)
• IV: Typical 1mg (Range: 0.5 - 2 mg)
• IM: Typical 1mg (Range: 0.5 - 2 mg)
• SL: Typical 1mg (Range: 0.5 - 2 mg)

Target Organ Systems

• digestive