Loratadine

Category: pharmacological

Aliases: Claritin

Pharmacological Mechanism

Second-generation H1 antagonist — minimal BBB penetration → low sedation. Active descarboethoxy metabolite (desloratadine) has long half-life supporting once-daily dosing.

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–10 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Histamine receptor pharmacology (inhibitor) — H1 (2nd-gen, peripheral selective)

Chemical Identifiers

• PubChem CID: 3957
• Formula: C22H23ClN2O2
• Molecular weight: 382.88 g/mol
• InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

References

• PMID 12852841