LL-37

Category: peptide

Aliases: Cathelicidin (human), CAMP, hCAP-18 C-terminal peptide

Pharmacological Mechanism

C-terminal cleavage product of hCAP-18, the only human cathelicidin. Amphipathic α-helix that disrupts bacterial membranes directly (especially Gram-negative). Also drives macrophage / neutrophil chemotaxis, P2X7 activation, and DNA-sensing via TLR9. Vitamin D3 is the primary transcription inducer of CAMP (link between vit-D status and innate immunity).

Target Organ Systems

• immune-hematologic

Interactions

• Vitamin D3 (synergistic): D3 is the principal transcriptional driver of cathelicidin (CAMP gene) expression.

Pathways It Modulates

• Antimicrobial + cosmetic peptides (inhibitor) — bacterial membrane disruption + immune modulation

Chemical Identifiers

• PubChem CID: 16198951
• Formula: C205H340N60O53
• Molecular weight: 4493 g/mol
• InChIKey: POIUWJQBRNEFGX-XAMSXPGMSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)N