Lisinopril

Category: pharmacological

Aliases: Prinivil, Zestril

Pharmacological Mechanism

ACE inhibitor — blocks angiotensin I → II conversion in vascular endothelium. Lowers blood pressure, reduces afterload in heart failure, slows diabetic nephropathy. Renally cleared unchanged; no CYP metabolism. Cough (~10%) from bradykinin accumulation.

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 20 mg (Range: 5–40 mg)

Target Organ Systems

• cardiovascular
• renal

Pathways It Modulates

• Bradykinin / kallikrein-kinin system (inhibitor) — ACE
• Renin-angiotensin-aldosterone axis (inhibitor) — ACE

Chemical Identifiers

• PubChem CID: 5362119
• Formula: C21H31N3O5
• Molecular weight: 405.49 g/mol
• InChIKey: RLAWWYSOJDYHDC-BZSNNMDCSA-N
• SMILES: C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O

References

• PMID 2844083