Lisinopril

Category: pharmacological

Aliases: Prinivil, Zestril

Pharmacological Mechanism

ACE inhibitor — blocks angiotensin I → II conversion in vascular endothelium. Lowers blood pressure, reduces afterload in heart failure, slows diabetic nephropathy. Renally cleared unchanged; no CYP metabolism. Cough (~10%) from bradykinin accumulation.

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 20mg (Range: 5 - 40 mg)

Target Organ Systems

• cardiovascular
• renal