Liraglutide

Category: peptide

Aliases: Victoza, Saxenda

Pharmacological Mechanism

GLP-1(7-37) analog with Arg-34 and palmitoyl (C-16) on Lys-26 via γGlu linker → albumin binding → 13 h t½ (vs. native GLP-1's 1.5 min). Daily SC dosing. Predated semaglutide; replaced for most indications by weekly agents.

Half-Life (t½)

SC: 13h

Dosing Guidelines

• SC: Typical 1.8mg (Range: 1.8 - 1.8 mg)

Target Organ Systems

• endocrine