Linezolid

Category: pharmacological

Aliases: Zyvox

Pharmacological Mechanism

Oxazolidinone — binds 23S rRNA of bacterial 50S subunit blocking 70S initiation complex formation. Active against MRSA + VRE. Reversible MAO inhibition → serotonin syndrome risk with SSRIs. Bone marrow suppression at courses > 14 days.

Half-Life (t½)

PO: 5h, IV: 5h

Dosing Guidelines

• PO: Typical 600mg (Range: 600 - 600 mg)

Target Organ Systems

• nervous
• musculoskeletal
• immune-hematologic