Linaclotide

Category: pharmacological

Aliases: Linzess

Pharmacological Mechanism

GC-C (guanylate cyclase-C) agonist — raises intestinal cGMP → CFTR-mediated chloride / bicarbonate / water secretion into lumen. Approved for chronic idiopathic constipation + IBS-C. Minimal systemic absorption → DDI-light. Diarrhea is the main dose-limiting side effect.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 0.145mg (Range: 0.072 - 0.29 mg)

Target Organ Systems

• digestive