Lemborexant

Category: sleep

Aliases: Dayvigo

Pharmacological Mechanism

Dual orexin receptor antagonist (DORA) — competitive antagonist at OX1R and OX2R. Suppresses wakefulness without GABA-A activation, so morning hangover is milder than benzodiazepines. ~17h half-life with active metabolite.

Half-Life (t½)

PO: 17h

Dosing Guidelines

• PO: Typical 5mg (Range: 5 - 10 mg)

Target Organ Systems

• nervous