Low-Dose Naltrexone

Category: other

Aliases: ldn, naltrexone

Pharmacological Mechanism

Transient mu-opioid antagonism; upregulates endogenous endorphins.

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 4.5 (Range: 0.5–4.5)

Target Organ Systems

• nervous

Pathways It Modulates

• Opioid receptor signaling (inhibitor) — μ-opioid (low-dose, paradoxical microglial modulation)

Chemical Identifiers

• PubChem CID: 45382306
• Formula: C25H23N6+
• Molecular weight: 341.41 g/mol
• InChIKey: CDOVNWNANFFLFJ-UHFFFAOYSA-O
• SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN=C4C(=CN[N+]4=C3)C5=CC=NC6=CC=CC=C56

References

• PMID 24526585