Lansoprazole

Category: pharmacological

Aliases: Prevacid

Pharmacological Mechanism

Irreversible H+/K+-ATPase inhibitor. CYP2C19 + CYP3A4 substrate. Available OTC; commonly co-administered with NSAIDs to mitigate gastric ulcers.

Half-Life (t½)

PO: 2h

Dosing Guidelines

• PO: Typical 30 mg (Range: 15–30 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Gastric acid secretion (inhibitor) — H+/K+-ATPase

Chemical Identifiers

• PubChem CID: 3883
• Formula: C16H14F3N3O2S
• Molecular weight: 369.36 g/mol
• InChIKey: MJIHNNLFOKEZEW-UHFFFAOYSA-N
• SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

References

• PMID 8803522