Labetalol

Category: pharmacological

Aliases: Trandate

Pharmacological Mechanism

Combined α1 + non-selective β-adrenergic blocker (~3:1 β:α IV, ~7:1 PO). BP-lowering without reflex tachycardia. Workhorse for hypertension in pregnancy + emergency BP control + pheochromocytoma pre-op management.

Half-Life (t½)

PO: 6h, IV: 6h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 1200 mg)

Target Organ Systems

• cardiovascular