Ketoconazole Shampoo

Category: topical

Aliases: Nizoral A-D

Pharmacological Mechanism

Topical 2% (Rx) and 1% (OTC) ketoconazole shampoo for dandruff + seborrheic dermatitis. Same fungal CYP51 inhibition as oral ketoconazole but minimal systemic absorption from short scalp contact.

Half-Life (t½)

TD: 12h

Dosing Guidelines

• TD: Typical 30mg (Range: 20 - 50 mg)

Target Organ Systems

• digestive
• integumentary