Kaempferol

Category: flavonoid

Aliases: 3,4′,5,7-tetrahydroxyflavone

Pharmacological Mechanism

Flavonol with ER-α binding (weak phytoestrogen activity), Nrf2 activation, and mTOR inhibition. Gut-microbial conversion yields phloroglucinol-type metabolites. Anti-angiogenic effects reported in tumour models (VEGF pathway modulation).

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 6.67 mg (Range: 5–10 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Nrf2 / Keap1 antioxidant response (activator) — Nrf2 + estrogen-receptor modulation

Chemical Identifiers

• PubChem CID: 5280863
• Formula: C15H10O6
• Molecular weight: 286.24 g/mol
• InChIKey: IYRMWMYZSQPJKC-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

References

• PMID 15113710