Isosorbide Mononitrate

Category: pharmacological

Aliases: ISMN, Imdur

Pharmacological Mechanism

Active metabolite of isosorbide dinitrate — bypasses hepatic first-pass nitrate conversion. Releases NO in vascular smooth muscle → cGMP → vasodilation; preferentially venous, reducing preload. Used for chronic stable angina + heart failure. Tolerance develops with continuous exposure → daily nitrate-free interval recommended.

Half-Life (t½)

PO: 5h

Dosing Guidelines

• PO: Typical 60 mg (Range: 20–240 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• PDE5 / NO-cGMP axis (activator) — NO release
• Vasodilator pharmacology (activator) — NO release

Chemical Identifiers

• PubChem CID: 27661
• Formula: C6H9NO6
• Molecular weight: 191.14 g/mol
• InChIKey: YWXYYJSYQOXTPL-SLPGGIOYSA-N
• SMILES: C1[C@@H]([C@@H]2[C@H](O1)[C@@H](CO2)O[N+](=O)[O-])O

References

• PMID 15146932