Irbesartan

Category: pharmacological

Aliases: Avapro

Pharmacological Mechanism

AT1 receptor blocker — strong renoprotection signal in IDNT trial for diabetic nephropathy. Once-daily dosing.

Half-Life (t½)

PO: 14h

Dosing Guidelines

• PO: Typical 150 mg (Range: 75–300 mg)

Target Organ Systems

• renal

Pathways It Modulates

• PPAR α / γ / δ nuclear receptor signaling (activator) — PPARγ (weak partial)
• Renin-angiotensin-aldosterone axis (inhibitor) — AT-1 receptor

Chemical Identifiers

• PubChem CID: 3749
• Formula: C25H28N6O
• Molecular weight: 428.53 g/mol
• InChIKey: YOSHYTLCDANDAN-UHFFFAOYSA-N
• SMILES: CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

References

• PMID 9246947