Ipratropium

Category: pharmacological

Aliases: Atrovent

Pharmacological Mechanism

Quaternary ammonium muscarinic antagonist — bronchodilation via M3 blockade in airway smooth muscle. Quaternary structure limits systemic absorption from inhaled route. Combined with salbutamol (Combivent) for acute COPD.

Half-Life (t½)

INH: 2h

Dosing Guidelines

• INH: Typical 0.04mg (Range: 0.02 - 0.04 mg)

Target Organ Systems

• respiratory