Insulin Glargine

Category: pharmacological

Aliases: Lantus, Toujeo, Basaglar

Pharmacological Mechanism

Long-acting basal insulin analog — A21Asn→Gly + B-chain Arg-Arg extension shifts pI to ~7, producing slow precipitation in subcutaneous tissue → flat 24h profile. Once-daily SC for T1D + T2D basal coverage.

Half-Life (t½)

SC: 18h

Dosing Guidelines

• SC: Typical 30IU (Range: 10 - 100 IU)

Target Organ Systems

• endocrine