Indomethacin

Category: pharmacological

Aliases: Indocin

Pharmacological Mechanism

Indole-acetic NSAID — potent non-selective COX inhibitor. First-line for acute gout + pericarditis. High CNS penetration → headache, dizziness, confusion in elderly. CYP2C9 substrate.

Half-Life (t½)

PO: 4.5h, IV: 4.5h, PR: 4.5h

Dosing Guidelines

• PO: Typical 50 mg (Range: 25–75 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Arachidonic acid cascade (inhibitor) — COX-1 + COX-2
• Bradykinin / kallikrein-kinin system (inhibitor) — COX (most potent NSAID for BK-PG cross-talk)

Chemical Identifiers

• PubChem CID: 3715
• Formula: C19H16ClNO4
• Molecular weight: 357.79 g/mol
• InChIKey: CGIGDMFJXJATDK-UHFFFAOYSA-N
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

References

• PMID 22913908