Indomethacin

Category: pharmacological

Aliases: Indocin

Pharmacological Mechanism

Indole-acetic NSAID — potent non-selective COX inhibitor. First-line for acute gout + pericarditis. High CNS penetration → headache, dizziness, confusion in elderly. CYP2C9 substrate.

Half-Life (t½)

PO: 4.5h, IV: 4.5h, PR: 4.5h

Dosing Guidelines

• PO: Typical 50mg (Range: 25 - 75 mg)

Target Organ Systems

• nervous
• digestive