Imipramine

Category: pharmacological

Aliases: Tofranil

Pharmacological Mechanism

Tertiary-amine TCA — first TCA approved (1959). Approved for depression + childhood enuresis. Active desipramine metabolite. Anticholinergic burden + cardiotoxicity at overdose are class issues.

Half-Life (t½)

PO: 16.7h

Dosing Guidelines

• PO: Typical 100mg (Range: 25 - 300 mg)

Target Organ Systems

• nervous