Ibandronate

Category: pharmacological

Aliases: Boniva

Pharmacological Mechanism

Aminobisphosphonate — once-monthly oral or once-quarterly IV dosing for postmenopausal osteoporosis. Lower vertebral-fracture-only evidence vs alendronate / risedronate (no demonstrated hip-fracture reduction).

Half-Life (t½)

PO: 240h, IV: 240h

Dosing Guidelines

• PO: Typical 150 mg (Range: 150–150 mg)

Target Organ Systems

• musculoskeletal

Pathways It Modulates

• Bone remodeling (inhibitor) — osteoclast farnesyl-PP synthase

Chemical Identifiers

• PubChem CID: 60852
• Formula: C9H23NO7P2
• Molecular weight: 319.23 g/mol
• InChIKey: MPBVHIBUJCELCL-UHFFFAOYSA-N
• SMILES: CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O

References

• PMID 24756462