Hydroxychloroquine

Category: pharmacological

Aliases: Plaquenil, HCQ

Pharmacological Mechanism

Aminoquinoline antimalarial — accumulates in lysosomes raising endosomal pH. Disrupts antigen processing + Toll-like receptor signaling. Used long-term for SLE + rheumatoid arthritis. Retinopathy risk requires baseline + annual ophthalmologic monitoring.

Half-Life (t½)

PO: 960h

Dosing Guidelines

• PO: Typical 400mg (Range: 200 - 600 mg)

Target Organ Systems

• immune-hematologic