Hydrocortisone

Category: hormone

Aliases: Cortef, Cortisone analog

Pharmacological Mechanism

Synthetic cortisol — same molecule as endogenous cortisol. Used as physiologic replacement in adrenal insufficiency at lower doses; pharmacologic anti-inflammatory at higher. Mineralocorticoid activity is non-trivial (unlike dexamethasone).

Half-Life (t½)

PO: 1.5h, IV: 1.5h, IM: 1.5h

Dosing Guidelines

Target Organ Systems