β-Hydroxy β-Methylbutyrate

Category: amino-acid

Aliases: HMB

Pharmacological Mechanism

Leucine metabolite (~5% of leucine flux) — anti-catabolic in skeletal muscle, slowing protein degradation. Most clinical benefit in catabolic states (cachexia, immobilization, very-detrained subjects); minimal in trained athletes. Calcium-HMB and free-acid HMB formulations differ in absorption.

Half-Life (t½)

PO: 2h

Dosing Guidelines

Target Organ Systems