Hexahydrocannabinol

Category: alkaloid

Aliases: hexahydrocannabinol, HHC

Pharmacological Mechanism

Hydrogenated (saturated C9–C10) analog of THC. A psychoactive CB1/CB2 agonist; commercial products are a mixture of two C9 epimers, (9R)- and (9S)-HHC, with the (9R) epimer reported to bind CB1/CB2 more favorably. Hemp-derived semi-synthetic.

Dosing Guidelines

• INH: Typical 10 (Range: 5–25)
• PO: Typical 20 (Range: 10–40)

Target Organ Systems

• nervous

Notes

PubChem CID 16050328. Occupancy SKIP: the one direct parent-HHC receptor paper (PMID:40704858) is molecular-docking only (no Ki); all numeric values found belong to synthetic HHC derivatives. No verbatim half-life (see AUTHORING_GAPS).

Chemical Identifiers

• PubChem CID: 16050328
• Formula: C21H32O2
• Molecular weight: 316.5 g/mol
• InChIKey: XKRHRBJLCLXSGE-VNCLPFQGSA-N
• SMILES: CCCCCC1=CC(=C2[C@@H]3CC(CC[C@H]3C(OC2=C1)(C)C)C)O