Hexarelin

Category: peptide

Aliases: Examorelin

Pharmacological Mechanism

Most potent GHSR-1a agonist among the GHRPs (2-MeTrp substitution drives receptor affinity). Also binds CD36 — distinct from pure GHSR action — explaining reported cardioprotective preclinical effects. Rapidly desensitises the receptor with daily use.

Half-Life (t½)

SC: 0.6h

Dosing Guidelines

• SC: Typical 133 mcg (Range: 100–200 mcg)

Target Organ Systems

• endocrine
• musculoskeletal

Pathways It Modulates

• Growth hormone / GHRH / GHS axis (activator) — GHS-R1a

Chemical Identifiers

• PubChem CID: 6918297
• Formula: C47H58N12O6
• Molecular weight: 887 g/mol
• InChIKey: RVWNMGKSNGWLOL-GIIHNPQRSA-N
• SMILES: CC1=C(C2=CC=CC=C2N1)C[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@H](CC5=CC=CC=C5)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC6=CN=CN6)N

References

• PMID 8126144