Haloperidol

Category: pharmacological

Aliases: Haldol

Pharmacological Mechanism

High-potency typical antipsychotic — strong D2 antagonist with minimal anticholinergic / antihistamine activity. EPS + tardive dyskinesia risk; QT prolongation at high IV doses. CYP3A4 + CYP2D6 substrate. IM decanoate enables monthly depot dosing.

Half-Life (t½)

PO: 29.6h, IV: 29.6h, IM: 18h

Dosing Guidelines

• PO: Typical 5 mg (Range: 0.5–30 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Dopamine receptor signaling (inhibitor) — D2 antagonist (high-potency typical)

Chemical Identifiers

• PubChem CID: 3559
• Formula: C21H23ClFNO2
• Molecular weight: 375.86 g/mol
• InChIKey: LNEPOXFFQSENCJ-UHFFFAOYSA-N
• SMILES: C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F

References

• PMID 15918525
• PMID 1533719
• PMID 1361536
• PMID 8301582
• PMID 8935801