Guanfacine

Category: stimulant

Aliases: Intuniv, Tenex

Pharmacological Mechanism

Selective α₂A-adrenergic agonist — prefrontal cortex postsynaptic α₂A activation enhances working memory + impulse control via cyclic-nucleotide gated channel modulation. Lower sedation than clonidine (less α2B activity).

Half-Life (t½)

PO: 17h

Dosing Guidelines

• PO: Typical 2 mg (Range: 1–4 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Adrenergic receptor signaling (activator) — α2A (central)

Chemical Identifiers

• PubChem CID: 3519
• Formula: C9H9Cl2N3O
• Molecular weight: 246.09 g/mol
• InChIKey: INJOMKTZOLKMBF-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl

References

• PMID 6994775
• PMID 1356570
• PMID 7029332