Guanfacine

Category: stimulant

Aliases: Intuniv, Tenex

Pharmacological Mechanism

Selective α₂A-adrenergic agonist — prefrontal cortex postsynaptic α₂A activation enhances working memory + impulse control via cyclic-nucleotide gated channel modulation. Lower sedation than clonidine (less α2B activity).

Half-Life (t½)

PO: 17h

Dosing Guidelines

Target Organ Systems