Goserelin

Category: hormone

Aliases: Zoladex

Pharmacological Mechanism

Synthetic decapeptide GnRH/LHRH agonist. Continuous depot exposure first causes a transient gonadotropin/sex-steroid surge ("flare"), then desensitizes pituitary GnRH receptors → castrate-level testosterone (men) or estradiol (women). Prostate/breast cancer, endometriosis.

Half-Life (t½)

SC: 4.2h

Dosing Guidelines

• SC: Typical 3.6 mg (Range: 3.6–10.8 mg)

Target Organ Systems

• endocrine
• reproductive

Chemical Identifiers

• PubChem CID: 5311128
• Formula: C59H84N18O14
• Molecular weight: 1269.4 g/mol
• InChIKey: BLCLNMBMMGCOAS-URPVMXJPSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NNC(=O)N)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

References

• PMID 10926349