Gonadorelin

Category: peptide

Aliases: GnRH, LHRH, Factrel, Lutrepulse

Pharmacological Mechanism

Native GnRH decapeptide. Pulsatile administration drives physiologic LH/FSH release; continuous administration paradoxically suppresses via GnRH-R desensitisation (the principle behind GnRH-agonist therapy for prostate cancer, endometriosis, precocious puberty). Commonly used in TRT protocols at 100–200 mcg SC 2×/week to maintain testicular function.

Half-Life (t½)

IV: 0.11h

Dosing Guidelines

• IV: Typical 11.7 mcg (Range: 5–25 mcg)
• SC: Typical 11.7 mcg (Range: 5–25 mcg)

Target Organ Systems

• endocrine
• reproductive

Interactions

• Testosterone Cypionate (synergistic): Gonadorelin is commonly included in TRT protocols to prevent HPG-axis shutdown / testicular atrophy.

Pathways It Modulates

• GnRH pulse generator (activator) — GnRH-R (pulsatile dosing)

Chemical Identifiers

• PubChem CID: 638793
• Formula: C55H75N17O13
• Molecular weight: 1182.3 g/mol
• InChIKey: XLXSAKCOAKORKW-AQJXLSMYSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6

References

• PMID 320223