Glyburide

Category: pharmacological

Aliases: Glibenclamide, DiaBeta

Pharmacological Mechanism

Second-generation sulfonylurea — K-ATP channel closure → insulin release. Hepatically metabolized (CYP3A4); active M1 metabolite contributes to hypoglycemia in renal impairment. Beers-list problematic in elderly.

Half-Life (t½)

PO: 9.7h

Dosing Guidelines

• PO: Typical 5mg (Range: 1.25 - 20 mg)

Target Organ Systems

• endocrine
• digestive
• renal